No. The United States no longer maintains comprehensive sanctions on Syria, effective July 1, 2025, following the issuance of the E.O. of June 30, 2025. You may send U.S.-origin food or medicine to Syria without a specific license from OFAC.
Furthermore, the Department of Commerce maintains jurisdiction over the export of most items to Syria. In the E.O. of June 30, 2025, the President waived requirements to impose certain export controls under the Syria Accountability and Lebanese Sovereignty Restoration Act of 2003 and the Chemical and Biological Weapons Control and Warfare Elimination Act of 1991. Please refer to the Department of Commerce for more specifics on export controls involving Syria.